Dr. Dai-Wen Pang is full professor of chemistry at Wuhan University (China), Director of the Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE, China), Co-Director of the Nano-BioCatEchem Laboratoire International Associé (LIA) du CNRS (CNRS and Universities of Wuhan-ENS Paris-Pierre et Marie Curie-Rennes 1-Xiamen), member of the National Steering Committee for Nanotechnology (China), member of the National Key Scientific Program of Nano Research (China), commissioner of the Evaluation Committee of the Chemistry Department of the National Natural Science Foundation of China (NSFC), head of the Creative Research Group (NSFC), 973 Chief Scientist, Vice Chairman of the Analytical Chemistry Division of Chinese Chemical Society, member of the Editorial Advisory Board of Analytical Chemistry (ACS), Associate Editor for New Journal of Chemistry (RSC, CNRS), the Technical Founder of Wuhan Jiayuan Quantum Dots Co., Ltd, and so on.
During the last 16 years he has been committing himself to developing fluorescent quantum dots (QDs) for biomedical imaging and biodiagnostics. In particular, he and his coworkers were the first to propose a novel strategy of “Space-Time Coupling” for controlled synthesis of QDs in living cells. This human-made biosynthesis has been expanded into in vitro cell-free quasi-biosystems to precisely fabricate ultrasmall and biocompatible multifunctionalized nanocrystals under benign conditions, which are very difficult to obtain by conventional synthesis strategies, such as near-infrared Ag2Se (1.5 nm) and ultrasmall near-infrared fluorescent-magnetic multifunctional Ag2Se@Mn QDs (1.8 nm). He also has established multiple methods for tagging QDs under mild and natural conditions, including 7 for the envelope, capsid and nucleic acids of enveloped viruses and 2 for cell-derived microvesicles. One of his major accomplishments is the development of a method for 3-D real-time dynamic tracking of quantum dot-labeled single viruses infecting their host cells, by which multiple stages of receptor-related, microtubule-dependent and endosome-associated influenza virus infection have been unraveled. In addition, he has developed a new strategy for electrochemical tuning of luminescent carbon nanodots, by which the size, surface oxidation state and corresponding luminescence properties of carbon nanodots can be modulated precisely. He is the author for over 250 research publications in peer-reviewed international journals, 3 books, 30 authorized patents and one national standard for quantum dots. He has delivered more than 180 invited lectures all over the world.