许小娟

博士 , 教授
研究方向: 高分子物理、多糖生物学
联系电话: 86-27-68754188
Email: xuxj@whu.edu.cn

                                                                                                                                                                                                                                                                    

教育与研究经历  

1993.9-1997.6,理学学士,武汉大学化学学院

1997.9-2002.6,理学博士,武汉大学化学与分子科学学院(导师:张俐娜教授)

2000.4-2001.3,特别研究生,日本大阪大学理学部高分子科学系(从事多糖溶液性质研究,导师:则末尚志教授)

2001.7-现在,助教、讲师、副教授、教授/博导,武汉大学化学与分子科学学院

2008.11-2010.10,日本学术振兴会(JSPS)外国人特别研究员,日本神户大学(从事多糖生物学研究)

                                                                                                                                                                                                                                                                    

研究领域与兴趣

一、高分子物理

1、多糖链结构及表征方法

2、多糖溶液(稀浓溶液性质、聚集、溶液-凝胶转变、自组装等)

3、多糖基复合物及功能

二、多糖生物学

1、多糖的生物活性及构效关系

2、多糖与细胞的相互作用及诱导的细胞内信号转导

                                                                                                                                                                                                                                                                    

学术兼职     

中国化学会高分子专业委员会高分子表征学科组委员

Bioactive Carbohydrates and Dietary Fibres 期刊编委

International Journal of Biochemistry and Molecular Biology Research  期刊编委

                                                                                                                                                                                                                                                                    

教学情况

本科生课程:《高分子导论》、《高分子合成与表征》

研究生课程:《高分子物理近代研究方法》、《高分子科学进展》

                                                                                                                                                                                                                                                                    

承担项目

1、国家自然科学基金215741022016.1-2019.12。(主持)

2、教育部新世纪优秀人才支持计划NCET-13-04422014.1-2016.12。(主持)

3、武汉大学自主科研项目(2042014kf0216),2014.1-2015.12(主持)

4、国家自然科学重点基金213340052014.1-2017.12。(参加)

5、武汉市“黄鹤英才计划”,2013.1-2016.12。(主持)

6、国家自然科学基金212741142013.1-2016.12。(主持)

7、国家自然科学基金208740782009.1-2011.12。(主持)

8、武汉市青年科技晨光计划200950431193 2009.1-2011.12。(主持)

9、国家自然科学基金204040102005.1-2007.12。(主持)

10、湖北省自然科学基金, 2005.1-2006.12。(主持)

                                                                                                                                                                                                                                                                    

代表性论文

1. Liu Q., Cao Y., Xu H., Li M., Xu X.*, Zhang L., Transfection efficiency and internalization of the gene carrier prepared from a triple helical b-glucan and polydeoxyadenylic acid in macrophage RAW264.7 cells, J. Mater. Chem. B, 2015, 3, 3789-3798.

2. Fang Y., Duan B., Lu A., Liu M., Liu H., Xu X.*, Zhang L.*, Intermolecular interaction and the extended wormlike chain conformation of chitin in NaOU/urea aqueous solution, Biomacromolecules, 2015,16,1410-1417.

3. Liu Q., Wang C.,  Cao Y.,  Xu X.*,  Zhang L., A novel gene delivery system prepared from beta-glucan and polydeoxyadenylic acid via disulfide bonds. J. Mater. Chem. B, 2014, 2, 933-944. (cover paper)

4. Jia X., Xu X.*, Zhang L. Synthesis and Stabilization of Gold Nanoparticles Induced by Denaturation and Renaturation of Triple Helical b-Glucan in Water. Biomacromolecules, 2013,14, 1787-1794.

5. Xu S., Lin Y., Huang J., Li Z., Xu X.*, Zhang L.*, Construction of high strength hollow fibers by self-assembly of a stiff polysaccharide with short branches in water. J. Mater., Chem. A, 2013, 1, 4198-4206.

6. Liu Q., Xu X.*, Zhang L., Luo X., Liang Y., Assembly of single-stranded polydeoxyadenylic acid and b-Glucan probed by the sensing platform of graphene oxide based on the fluorescence resonance energy transfer and fluorescence anisotropy. Analyst, 2013, 138, 2661-2668.

7. Xu X.*, Yasuda M., Mizuno M., Ashida H.* β-Glucan from Saccharomyces cerevisiae reduces lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages. Biochim. Biophys. Acta, 2012, 1820, 1656-1663.

8. Xu X.*, Yasuda M., Nakamura-Tsuruta S., Mizuno M., Ashida H.*, b-glucan from Lentinus edodes inhibits nitric oxide and tumor necrosis factor-a and phosphorylation of mitogen-activated protein kinases in lipopolysaccharide stimulated murine RAW 264.7 macrophages. J. Biol. Chem., 2012, 287, 871-878.

9. Xu X.*, Chen P., Zhang L., Ashida H., Immunomodulatory b-glucan from Lentinus edodes activates mitogen-activated protein kinases and nuclear factor-kB in murine RAW 264.7 macrophages. J. Biol. Chem., 2011, 286, 31194-31198.

10.Xu S., Xu X.*, Zhang L.* Branching structure and chain conformation of water-soluble glucan extracted from Auricularia Auricula-Judae. J. Agric. Food Chem.2012, 60, 3498-3506.

11. Li S., Zhang Y., Xu X., Zhang L., Triple helical polysaccharide-induced good dispersion of silver nanoparticles in water. Biomacromolecules, 2011, 12, 2864-2871

12.Zhang Y, Xu X.*, Zhang L., Dynamic viscoelastic behavior of triple helical Lentinan in water. Effects of concentration and molecular weight. Polymer, 2007, 48, 6681-6690.

13.Xu X., Zhang X., Zhang L., Wu C., Collapse and association of denatured lentinan in water / dimethylsulfoxide solution, Biomacromolecules, 2004, 5, 1893-189